Anatomy > Publikationen

Publikationen

2025 and 2026

Dembitskaya Y, Okuda K, Brugiere T, Girard J, Gaikwad P, Nägerl UV. Pan-Optical Shadow Imaging of Brain Microanatomy. Methods Mol Biol. 2026; PMID: 42091817
Berbeira-Santana M*, Peregrina C,* Okuda K*, Zhou JC, Carrasquero-Ordaz M, Roberts AV, Thomas AE, Haanappel E, Chavent M, el Omari K, Baker LA, Pederick DT, Pardon E, Steyaert J, Nägerl UV^, del Toro D^, Seiradake E^. Structurally exclusive Teneurin complexes orchestrate divergent programs in early cortical development. Nature Comm. 2026 *equal contribution ^co-correspondance
Bayraktar G, Dannersø JK, Hansen DS, Schmidt Laursen L, Nägerl UV, Nissen P, Double periodicity of the AnkyrinG-associated complex in the axon initial segment, bioRxiv, 2026, https://doi.org/10.64898/2026.04.25.720723
Bobo-Jimenez V, Gomila S, Lapresa R, Agulla J, Angibaud J, Sanchez-Moran I, Delgado-Esteban M, González-Rodriguez A, Fernández-Jaén A, Ramos-Cabrer P, Nägerl UV, Bolaños JP, Almeida A, Perinatal liver sympathetic innervation governs body size, Commun Biol., 2026, PMID: 41826417
Arizono M, Idziak A, Nägerl UV. Live STED imaging of functional neuroanatomy. Nat Protoc. 2025;20(8):2261–2285. doi: 10.1038/s41596-024-01132-6.
Roos J, Bancelin S, Nägerl UV. FASER: a tool for vectorial point spread function simulation with applications in stimulated emission depletion microscopy. Neurophotonics. 2025;12(1):017801. doi: 10.1117/1.NPh.12.1.017801.
Griswold JM, Bonilla-Quintana M, Pepper R, Lee CT, Raychaudhuri S, Ma S, Gan Q, Syed S, Zhu C, Bell M, Suga M, Yamaguchi Y, Chéreau R, Nägerl UV, Knott G, Rangamani P, Watanabe S. Membrane mechanics dictate axonal pearls-on-a-string morphology and function. Nat Neurosci. 2025;28(1):49–61. doi: 10.1038/s41593-024-01813-1.
Brenner E, Hägerling R, Schacht V, Schrader K, Wilting J. Definition, Epidemiology and Pathophysiology of Lymphoedema. Cells. 2025;14(24):1955. doi: 10.3390/cells14241955.
Schmidt Schultz TH, Schultz M. Identification of typical marker proteins of Treponema pallidum in compact human bone using morphological and biochemical techniques. Scientific Reports. 2025;15(1):28743.
Becker J, Jeon C, Wilting J. In vitro and in ovo characterization of Ewing sarcoma cell lines: Comparison with neuroblastoma cell lines and lymphatic endothelial cells. Cell Signal. 2025;135:112072. doi: 10.1016/j.cellsig.2025.112072.
Rajput M, Malik IA, Methi A, Cortés Silva JA, Fey D, Wirths O, Fischer A, Wilting J, von Arnim CAF. Cognitive decline and neuroinflammation in a mouse model of obesity: An accelerating role of ageing. Brain Behav Immun.2025;125:226–239. doi: 10.1016/j.bbi.2024.12.154.
Barateli N, Iankoshvili G, Tsikolia N, Seropian A, Tarkhnishvili D. The tail of the two: a study of twin embryos in Darevskia lizards. Amphibia-Reptilia. 2025;46(2):241–248.
Tsikolia N, Nguyen DTL, Tee YH. Mechanisms of left–right symmetry breaking across scales. Curr Opin Cell Biol.2025;95:102564.
Wilting J, Becker J, Tsikolia N. Embryonic mesenchyme, mesenchymal tumors and mesenchymal stem cells: need for clarification of cell types and standardization of biomedical terminology. Cell Mol Life Sci. 2025;82(1):401.
Pieper TK, Tsikolia N. Left-right symmetry breaking: learning from the chicken. Front Cell Dev Biol. 2025;13:1672263.
Männer J. Congenital Isolation of a Common Carotid Artery: A Review of Cases, Phenotypes, and Embryology of a Rare Anomaly of the Aortic Arch System. Pediatr Cardiol. 2025;1–10.
Othman T, Alsaiad AMA, Jijeh AM, Männer J, Yelbuz TM. Ventricular Topology in Congenital Heart Defects Associated with Heterotaxy: Can We Find Patterns Reflecting the Syndrome-Specific Tendency for Visceral Symmetry? J Cardiovasc Dev Dis. 2025;12(11):430.
Ishida N, Kanahashi T, Matsubayashi J, Imai H, Männer J, Yamada S, Takakuwa T. Change in diameters of the small intestine according to embryonic and early fetal growth. J Anat. 2025.
Takakuwa T, Kakeya M, Ishida N, Kanahashi T, Fujii S, Männer J, Yamada S. Superior mesenteric artery during intestinal loop formation and its positional changes from the extracoelom to the abdominal cavity. Cells Tissues Organs. 2025.
Kanahashi T, Imai H, Otani H, Yamada S, Männer J, Takakuwa T. Boundary Formation of the Human Caudal Foregut During the Early Fetal Period: Three-Dimensional Analysis Using T1-Weighted and Diffusion Tensor Images. Cells Tissues Organs. 2025.

Book chapters / Buchbeiträge

Männer J. Embryologie des Blut- und Lymphgefäßsystems: Allgemeiner Fahrplan und Mechanismen der embryonalen Gefäßbildung. In: Gefäßerkrankungen bei Kindern und Jugendlichen. Berlin, Heidelberg: Springer Berlin Heidelberg; 2025. pp. 3–17. ISBN: 978-3-662-68515-0; ISBN: 978-3-662-68516-7 (eBook).

Wilting J, Chao TI. Lymph and Brain. In: Applied Lymphology: Basics | Daily Practice | Perspectives. Cham: Springer Nature Switzerland; 2025. pp. 395–404. ISBN: 978-3-031-77734-2; ISBN: 978-3-031-77734-9 (eBook).

Übersichtsartikel zum Einstieg

Arizono, M., & Nägerl, U. V. (2022). Plus vive, plus nette : la microscopie STED du cerveau. Photoniques, 114, 36–37. https://doi.org/10.1051/photon/202211436

Dieser Artikel bietet einen Überblick über die STED-Mikroskopie in der Neurowissenschaft. Die Autoren erläutern, wie diese Technik es ermöglicht, lebende Gehirnzellen im Nanometerbereich abzubilden und damit wichtige Erkenntnisse über deren Struktur und Funktion zu gewinnen.

Arizono, M., Bancelin, S., Bethge, P., Chéreau, R., Idziak, A., Inavalli, V. V. G. K., Pfeiffer, T., Tønnesen, J., & Nägerl, U. V. (2021). Nanoscale imaging of the functional anatomy of the brain. Neuroforum, Advance online publication. https://doi.org/10.1515/nf-2021-0004

Der Übersichtsartikel erläutert die Grundlagen der STED-Mikroskopie sowie deren technische Weiterentwicklungen und Anwendungen in der Hirnforschung. Er zeigt, wie diese Technik zur Aufklärung nanoskaliger Strukturen und Prozesse in lebenden Gehirnzellen beiträgt.

Arizono, M., Idziak, A., & Nägerl, U. V. (2021). Il faut être trois pour danser le tango – Illuminer les signaux Ca2+ des synapses tripartites. Médecine/Sciences, 37(2), 127–129. https://doi.org/10.1051/medsci/2020275

Der Artikel betont die aktive Rolle von Astrozyten bei der synaptischen Informationsverarbeitung. Mithilfe moderner Bioimaging-Techniken konnten schnelle, lokal begrenzte Ca²⁺-Signale in Astrozyten sichtbar gemacht werden, die eine fein abgestimmte Interaktion mit benachbarten Synapsen ermöglichen.

Arizono, M., Bancelin, S., & Nägerl, U. V. (2020). Visualiser l’espace extracellulaire du cerveau par imagerie super-résolutive en contraste inversé. Médecine/Sciences, 36(6–7), 559–561. https://doi.org/10.1051/medsci/2020105

Der Artikel beschreibt eine neue Technik zur Visualisierung des extrazellulären Raums im Gehirn mithilfe von invertiertem Kontrast und STED-Mikroskopie. Diese Methode ermöglicht die Untersuchung nanoskaliger Hirnstrukturen unter physiologischen Bedingungen und verbessert das Verständnis der zellulären Organisation im Gehirn

Nägerl, V. (2019). Schattenriss des Gehirns. Gehirn & Geist, (08), 56–59.

Der Artikel beschreibt ein innovatives bildgebendes Verfahren namens SUSHI (Super-Resolution Shadow Imaging), das es erlaubt, lebendes Hirngewebe hochaufgelöst darzustellen, indem der extrazelluläre Raum statt der Zellen selbst eingefärbt wird. Diese Methode eröffnet neue Perspektiven für die Kartierung neuronaler Netzwerke in intaktem Gewebe.

Arizono, M., & Nägerl, U. V. (2019). ライブ超解像イメージングによる三者間シナプスのアストロサイト信号の解明 [Untersuchung von Astrozytensignalen an tripartiten Synapsen mittels Live-Superresolution-Imaging]. 実験医学 (Jikken Igaku), 37(Sonderheft 17), 189–190.

Im Fokus dieses japanischen Artikels steht die Untersuchung von Astrozyten-Ca²⁺-Signalen an tripartiten Synapsen mittels Live-STED-Mikroskopie. Die Autoren zeigen, wie diese hochaufgelöste Technik hilft, die komplexe Dynamik und Lokalisation solcher Signale besser zu verstehen.

Chéreau, R., Angibaud, J., & Nägerl, U. V. (2018). La plasticité axonale révélée par l’imagerie super-résolution STED. Médecine/Sciences, 34(1), 17–18. https://doi.org/10.1051/medsci/20183401005

Mit Hilfe von STED-Mikroskopie kann die axonale Plastizität in lebendem Hirngewebe auf einer bislang unerreichten Auflösung untersucht werden. Die Autoren zeigen, dass sich feinste strukturelle Veränderungen mit neuronaler Aktivität korrelieren lassen – ein bedeutender Schritt für das Verständnis synaptischer Dynamik.

Reviews

Arizono M, Idziak A, Quici F, Nägerl UV.
Getting sharper: the brain under the spotlight of super-resolution microscopy. Trends in Cell Biology. 2023 Feb;33(2):148–161. PMID: 35906123
Fuhrmann M, Gockel N, Arizono M, Dembitskaya Y, Nägerl UV, Pennacchietti F, Damenti M, Testa I, Willig KI.
Super-resolution microscopy opens new doors to life at the nanoscale. Journal of Neuroscience. 2022 Nov 9;42(45):8488–8497. PMID: 36351828
Bohr T, Hjorth PG, Holst SC, Hrabětová S, Kiviniemi V, Lilius T, Lundgaard I, Mardal KA, Martens EA, Mori Y, Nägerl UV, Nicholson C, Tannenbaum A, Thomas JH, Tithof J, Benveniste H, Iliff JJ, Kelley DH, Nedergaard M.
The glymphatic system: current understanding and modeling. iScience. 2022 Aug 20;25(9):104987. PMID: 36093063
Arizono M, Nägerl UV.
Deciphering the functional nano-anatomy of the tripartite synapse using stimulated emission depletion microscopy. Glia. 2022 Apr;70(4):607–618. PMID: 34664734
Abdelfattah AS et al.
Neurophotonic tools for microscopic measurements and manipulation: status report. Neurophotonics. 2022 Jan;9(Suppl 1):013001. PMID: 35493335

Original Research Works (AG Nägerl)

Bayraktar G, Dannersø JK, Hansen DS, Schmidt Laursen L, Nägerl UV, Nissen P, Double periodicity of the AnkyrinG-associated complex in the axon initial segment, bioRxiv, 2026, https://doi.org/10.64898/2026.04.25.720723
Berbeira-Santana M*, Peregrina C,* Okuda K*, Zhou JC, Carrasquero-Ordaz M, Roberts AV, Thomas AE, Haanappel E, Chavent M, el Omari K, Baker LA, Pederick DT, Pardon E, Steyaert J, Nägerl UV^, del Toro D^, Seiradake E^. Structurally exclusive Teneurin complexes orchestrate divergent programs in early cortical development. Nature Comm. 2026 *equal contribution ^co-correspondance
Bobo-Jimenez V, Gomila S, Lapresa R, Agulla J, Angibaud J, Sanchez-Moran I, Delgado-Esteban M, González-Rodriguez A, Fernández-Jaén A, Ramos-Cabrer P, Nägerl UV, Bolaños JP, Almeida A, Perinatal liver sympathetic innervation governs body size, Commun Biol., 2026, PMID: 41826417.
Estaún-Panzano J, Dembitskaya Y, Calaresu I, Nandi S, Gresil Q, Doudnikoff E, Leste-Laserre T, Amédée T, Cognet L, Groc L, Nägerl UV, Bezard E. Mapping of the extracellular space in amyloid plaque-rich cortex. Adv Sci. 2025 Oct 24:e15674. PMID: 41133799
Arizono M, Idziak A, Nägerl UV, Live STED imaging of functional neuroanatomy, Nat Protoc, 2025, PMID 40087378
Roos J, Bancelin S, Nägerl UV, FASER: a tool for vectorial point-spread function simulation with applications in stimulated emission depletion microscopy, Neurophotonics, 2025, PMID 39944080
Griswold JM, Bonilla-Quintana M, Pepper R, Lee CT, Raychaudhuri S, Ma S, Gan Q, Syed S, Zhu C, Bell M, Suga M, Yamaguchi Y, Chéreau R, Nägerl UV, Knott G, Rangamani P, Watanabe S, Membrane mechanics dictate axonal pearls- on-a-string morphology and function, Nat Neurosci, 2025, PMID 39623218
Devor A, Abdalmalak A, Akkin T, Aponte Y, Augustine GJ, Brigadoi S, Buckley EM, Campbell RE, Carp SA, Chatton JY, Chen JL, Cheng JX, Cooper RJ, Dan I, Drew PJ, Durduran T, Emiliani V, Fellin T, Foust AJ, Fu L, Gandjbakhche A, Gervain J, Gilad A, Codina EG, Han X, Hillman EM, Hochgeschwender U, Hu S, Ji N, Kara P, Kim BM, Ko TS, Kuzum D, Lecoq J, Mesquita RC, Murphy TH, Nägerl UV, Nishimura N, Ono Y, Ozana N, Pavone FS, Peterka DS, Pisanello F, Roe AW, Shih AY, Shoham S, St-Pierre F, Tak S, Tian L, Wang K, Wolf M, Yi J, Yizhar O, Yucel MA, On the Power of Constructive Criticism, Neurophotonics, 2024, PMID 39713177
Roos J, Bancelin S, Delaire T, Wilhelmi A, Levet F, Engelhardt M, Viasnoff V, Galland R, Nägerl UV, Sibarita JB, Arkitekt: streaming analysis and real-time workflows for microscopy, Nat Methods, 2024, PMID 39294366
De Koninck Y, Alonso J, Bancelin S, B”Łque JC, B”langer E, Bouchard C, Canossa M, Chaniot J, Choquet D, Crocheti‘re Mé, Cui N, Danglot L, De Koninck P, Devor A, Ducros M, Getz AM, Haouat M, Hern⁄ndez IC, Jowett N, Keramidis I, Larivi‘re-Loiselle C, Lavoie-Cardinal F, MacGillavry HD, Malko“ A, Mancinelli M, Marquet P, Minderler S, Moreaud M, Nägerl UV, Papanikolopoulou K, Paquet ME, Pavesi L, Perrais D, Sansonetti R, Thunemann M, Vignoli B, Yau J, Zaccaria C, Understanding the nervous system: lessons from Frontiers in Neurophotonics, Neurophotonics, 2024, PMID 38545127
Bak MS, Park H, Yoon H, Chung G, Shin H, Shin S, Kim TW, Lee K, Nägerl UV, Kim SJ, Kim SK, Machine learning-based evaluation of spontaneous pain and analgesics from cellular calcium signals in the mouse primary somatosensory cortex using explainable features, Front Mol Neurosci, 2024, PMID 38450042
Le Bourdellès G, Mercier L, Roos J, Bancelin S, Nägerl UV, Impact of a tilted coverslip on two-photon and STED microscopy, Biomed Opt Express, 2024, PMID 38404309
Dembitskaya Y, Boyce AKJ, Idziak A, Pourkhalili Langeroudi A, Arizono M, Girard J, Le Bourdellès G, Ducros M, Sato-Fitoussi M, Ochoa de Amezaga A, Oizel K, Bancelin S, Mercier L, Pfeiffer T, Thompson RJ, Kim SK, Bikfalvi A, Nägerl UV, Shadow imaging for panoptical visualization of brain tissue in vivo, Nat Commun, 2023, PMID 37828018
Valiente-Gabioud AA, Garteizgogeascoa SuŒer I, Idziak A, Fabritius A, Basquin J, Angibaud J, Nägerl UV, Singh SP, Griesbeck O, Fluorescent sensors for imaging of interstitial calcium, Nat Commun, 2023, PMID 37798285
Idziak A, Inavalli VVGK, Bancelin S, Arizono M, Nägerl UV, The Impact of Chemical Fixation on the Microanatomy of Mouse Organotypic Hippocampal Slices, eNeuro, 2023, PMID 37709524
Bancelin S, Mercier L, Roos J, Belkadi M, Pfeiffer T, Kim SK, Nägerl UV, Imaging dendritic spines in the hippocampus of a living mouse by 3D- stimulated emission depletion microscopy, Neurophotonics, 2023, PMID 37215638
Grassi D, Idziak A, Lee A, Calaresu I, Sibarita JB, Cognet L, Nägerl UV, Groc L, Nanoscale and functional heterogeneity of the hippocampal extracellular space, Cell Rep, 2023, PMID 37149864
Denizot A, Arizono M, Nägerl UV, Berry H, De Schutter E, Control of Ca²⁺ signals by astrocyte nanoscale morphology at tripartite synapses, Glia, 2022, PMID 36097958
Bohr T, Hjorth PG, Holst SC, Hrab " tov⁄ S, Kiviniemi V, Lilius T, Lundgaard I, Mardal KA, Martens EA, Mori Y, Nägerl UV, Nicholson C, Tannenbaum A, Thomas JH, Tithof J, Benveniste H, Iliff JJ, Kelley DH, Nedergaard M, The glymphatic system: Current understanding and modeling, iScience, 2022, PMID 36093063
Arizono M, Nägerl UV, Deciphering the functional nano-anatomy of the tripartite synapse using stimulated emission depletion microscopy, Glia, 2022, PMID 34664734
Bancelin S, Mercier L, Murana E, Nägerl UV, Aberration correction in stimulated emission depletion microscopy to increase imaging depth in living brain tissue, Neurophotonics, 2021, PMID 34136589
Arizono M, Inavalli VVGK, Bancelin S, Fern⁄ndez-Monreal M, Nägerl UV, Super- resolution shadow imaging reveals local remodeling of astrocytic microstructures and brain extracellular space after osmotic challenge, Glia, 2021, PMID 33710691
Cassereau J, Courdavault V, Nägerl UV, Turning up the Green Light, Trends Cell Biol, 2021, PMID 33386190
Imig C, LŠpez-Murcia FJ, Maus L, Garc™a-Plaza IH, Mortensen LS, Schwark M, Schwarze V, Angibaud J, Nägerl UV, Taschenberger H, Brose N, Cooper BH, Ultrastructural Imaging of Activity-Dependent Synaptic Membrane- Trafficking Events in Cultured Brain Slices, Neuron, 2020, PMID 32991831
Henneberger C, Bard L, Panatier A, Reynolds JP, Kopach O, Medvedev NI, Minge D, Herde MK, Anders S, Kraev I, Heller JP, Rama S, Zheng K, Jensen TP, Sanchez- Romero I, Jackson CJ, Janovjak H, Ottersen OP, Nagelhus EA, Oliet SHR, Stewart MG, Nägerl UV, Rusakov DA, LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia, Neuron, 2020, PMID 32976770
Arizono M, Inavalli VVGK, Panatier A, Pfeiffer T, Angibaud J, Levet F, Ter Veer MJT, Stobart J, Bellocchio L, Mikoshiba K, Marsicano G, Weber B, Oliet SHR, Nägerl UV, Structural basis of astrocytic Ca²⁺ signals at tripartite synapses, Nat Commun, 2020, PMID 32312988
Stolp B, Thelen F, Ficht X, Altenburger LM, Ruef N, Inavalli VVGK, Germann P, Page N, Moalli F, Raimondi A, Keyser KA, Seyed Jafari SM, Barone F, Dettmer MS, Merkler D, Iannacone M, Sharpe J, Schlapbach C, Fackler OT, Nägerl UV, Stein JV, Salivary gland macrophages and tissue-resident CD8⁺ T cells cooperate for homeostatic organ surveillance, Sci Immunol, 2020, PMID 32245888
Levet F, Tonnesen J, Nägerl UV, Sibarita JB, SpineJ: A software tool for quantitative analysis of nanoscale spine morphology, Methods, 2020, PMID 32006677
Inavalli VVGK, Lenz MO, Butler C, Angibaud J, Compans B, Levet F, Tonnesen J, Rossier O, Giannone G, Thoumine O, Hosy E, Choquet D, Sibarita JB, Nägerl UV, A super-resolution platform for correlative live single-molecule imaging and STED microscopy, Nat Methods, 2019, PMID 31636458
Denizot A, Arizono M, Nägerl UV, Soula H, Berry H, Simulation of calcium signaling in fine astrocytic processes: Effect of spatial properties on spontaneous activity, PLoS Comput Biol, 2019, PMID 31425510
Pfeiffer T, Poll S, Bancelin S, Angibaud J, Inavalli VK, Keppler K, Mittag M, Fuhrmann M, Nägerl UV, Chronic 2P-STED imaging reveals high turnover of dendritic spines in the hippocampus in vivo, Elife, 2018, PMID 29932052
Androuin A, Potier B, Nägerl UV, Cattaert D, Danglot L, Thierry M, Youssef I, Triller A, Duyckaerts C, El Hachimi KH, Dutar P, Delatour B, Marty S, Evidence for altered dendritic spine compartmentalization in Alzheimer's disease and functional effects in a mouse model, Acta Neuropathol, 2018, PMID 29696365
Tonnesen J, Inavalli VVGK, Nägerl UV, Super-Resolution Imaging of the Extracellular Space in Living Brain Tissue, Cell, 2018, PMID 29474910
Ter Veer MJT, Pfeiffer T, Nägerl UV, Two-Photon STED Microscopy for Nanoscale Imaging of Neural Morphology In Vivo, Methods Mol Biol, 2017, PMID 28924658
Bobo-Jiménez V, Delgado-Esteban M, Angibaud J, Sanchez-Moran I, de la Fuente A, Yajeya J, Nägerl UV, Castillo J, BolaŒos JP, Almeida A, APC/Cdh1-Rock2 pathway controls dendritic integrity and memory, Proc Natl Acad Sci U S A, 2017, PMID 28396402
Chéreau R, Saraceno GE, Angibaud J, Cattaert D, Nägerl UV, Super-resolution imaging reveals activity-dependent plasticity of axon morphology linked to changes in action potential conduction velocity, Proc Natl Acad Sci U S A, 2017, PMID 28115721
Nägerl UV, Sibarita JB, Special Section Guest Editorial: Super- resolution microscopy of neural structure and function, Neurophotonics, 2016, PMID 28042586
Pfeiffer T, Avignone E, Nägerl UV, Induction of hippocampal long-term potentiation increases the morphological dynamics of microglial processes and prolongs their contacts with dendritic spines, Sci Rep, 2016, PMID 27604518
Tonnesen J, Nägerl UV, Dendritic Spines as Tunable Regulators of Synaptic Signals, Front Psychiatry, 2016, PMID 27340393
Viana da Silva S, Haberl MG, Zhang P, Bethge P, Lemos C, Gonzalves N, Gorlewicz A, Malezieux M, Gonzalves FQ, Grosjean N, Blanchet C, Frick A, Nägerl UV, Cunha RA, Mulle C, Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors, Nat Commun, 2016, PMID 27312972
Mohapatra N, Tonnesen J, Vlachos A, Kuner T, Deller T, Nägerl UV, Santamaria F, Jedlicka P, Spines slow down dendritic chloride diffusion and affect short- term ionic plasticity of GABAergic inhibition, Sci Rep, 2016, PMID 26987404
Barnes SA, Wijetunge LS, Jackson AD, Katsanevaki D, Osterweil EK, Komiyama NH, Grant SG, Bear MF, Nägerl UV, Kind PC, Wyllie DJ, Convergence of Hippocampal Pathophysiology in Syngap+/- and Fmr1-/y Mice, J Neurosci, 2015, PMID 26558778
Avignone E, Lepleux M, Angibaud J, Nägerl UV, Altered morphological dynamics of activated microglia after induction of status epilepticus, J Neuroinflammation, 2015, PMID 26538404
Chéreau R, Tonnesen J, Nägerl UV, STED microscopy for nanoscale imaging in living brain slices, Methods, 2015, PMID 26070997
Panatier A, Arizono M, Nägerl UV, Dissecting tripartite synapses with STED microscopy, Philos Trans R Soc Lond B Biol Sci, 2014, PMID 25225091
Wijetunge LS, Angibaud J, Frick A, Kind PC, Nägerl UV, Stimulated emission depletion (STED) microscopy reveals nanoscale defects in the developmental trajectory of dendritic spine morphogenesis in a mouse model of fragile X syndrome, J Neurosci, 2014, PMID 24790210
Tonnesen J, Katona G, Rozsa B, Nägerl UV, Spine neck plasticity regulates compartmentalization of synapses, Nat Neurosci, 2014, PMID 24657968
Bethge P, Chéreau R, Avignone E, Marsicano G, Nägerl UV, Two- photon excitation STED microscopy in two colors in acute brain slices, Biophys J, 2013, PMID 23442956
Tonnesen J, Nägerl UV, Two-color STED imaging of synapses in living brain slices, Methods Mol Biol, 2013, PMID 23086870
Tonnesen J, Nägerl UV, Superresolution imaging for neuroscience, Exp Neurol, 2013, PMID 23063602
Willig KI, Nägerl UV, Stimulated emission depletion (STED) imaging of dendritic spines in living hippocampal slices, Cold Spring Harb Protoc, 2012, PMID 22550296
Tonnesen J, Nadrigny F, Willig KI, Wedlich-Sıldner R, Nägerl UV, Two-color STED microscopy of living synapses using a single laser-beam pair, Biophys J, 2011, PMID 22098754
Herzog E, Nadrigny F, Silm K, Biesemann C, Helling I, Bersot T, Steffens H, Schwartzmann R, Nägerl UV, El Mestikawy S, Rhee J, Kirchhoff F, Brose N, In vivo imaging of intersynaptic vesicle exchange using VGLUT1 Venus knock- in mice, J Neurosci, 2011, PMID 22031900
Urban NT, Willig KI, Hell SW, Nägerl UV, STED nanoscopy of actin dynamics in synapses deep inside living brain slices, Biophys J, 2011, PMID 21889466
Li Q, Deng Z, Zhang Y, Zhou X, Nägerl UV, Wong ST, A global spatial similarity optimization scheme to track large numbers of dendritic spines in time-lapse confocal microscopy, IEEE Trans Med Imaging, 2011, PMID 21047709
Nägerl UV, Bonhoeffer T, Imaging living synapses at the nanoscale by STED microscopy, J Neurosci, 2010, PMID 20631162
Becker N, Wierenga CJ, Fonseca R, Bonhoeffer T, Nägerl UV, LTD induction causes morphological changes of presynaptic boutons and reduces their contacts with spines, Neuron, 2008, PMID 19038217
Nägerl UV, Willig KI, Hein B, Hell SW, Bonhoeffer T, Live-cell imaging of dendritic spines by STED microscopy, Proc Natl Acad Sci U S A, 2008, PMID 19028874
Fonseca R, Vabulas RM, Hartl FU, Bonhoeffer T, Nägerl UV, A balance of protein synthesis and proteasome-dependent degradation determines the maintenance of LTP, Neuron, 2006, PMID 17046687
Fonseca R, Nägerl UV, Bonhoeffer T, Neuronal activity determines the protein synthesis dependence of long-term potentiation, Nat Neurosci, 2006, PMID 16531998
Kawakami N, Nägerl UV, Odoardi F, Bonhoeffer T, Wekerle H, Imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion, title missing, J Exp Med, 2005, PMID 15939794
Fonseca R, Nägerl UV, Morris RG, Bonhoeffer T, Competing for memory: hippocampal LTP under regimes of reduced protein synthesis, Neuron, 2004, PMID 15603743
Nägerl UV, Eberhorn N, Cambridge SB, Bonhoeffer T, Bidirectional activity-dependent morphological plasticity in hippocampal neurons, Neuron, 2004, PMID 15572108
Görtz W, Nägerl UV, Nägerl H, Thomsen M, Spatial micromovements of uncemented femoral components after torsional loads, J Biomech Eng, 2002, PMID 12596639
Nägerl UV, Novo D, Mody I, Vergara JL, Binding kinetics of Calbindin-D(28k) determined by flash photolysis of caged Ca²⁺, Biophys J, 2000, PMID 11106608
Thomsen M, Görtz A, Nägerl UV, Kubein-Meesenburg D, Görtz W, Fanghänel J, Nägerl H, Bending vibrations of the femur and the oscillatory behavior of a cemented femoral hip endoprosthesis, J Biomech Eng, 2000, PMID 11036566
Nägerl UV, Mody I, Jeub M, Lie AA, Elger CE, Beck H, Surviving granule cells of the sclerotic human hippocampus have reduced Ca²⁺ influx because of a loss of calbindin-D(28k) in temporal lobe epilepsy, J Neurosci, 2000, PMID 10684884
Nägerl UV, Mody I, Calcium-dependent inactivation of high- threshold calcium currents in human dentate gyrus granule cells, J Physiol, 1998, PMID 9547379

Original Research Works (AG Dresbach)

Kapoor R, Do TT, Schwenzer N, Petrovic A, Dresbach T, Lehnart SE, Fernández-Busnadiego R, Moser T, Establishing synthetic ribbon-type active zones in a heterologous system, eLife, 2026, DOI: 10.7554/eLife.98254.
Domart F, Garlick E, Jansen I, do Rego Barros Fernandes Lima MA, Dresbach T, 3D MINFLUX combined with DNA-PAINT resolves the arrangement of Bassoon at active zones, bioRxiv, 2025, DOI: 10.1101/2025.09.03.673830.
Do TT, Siegert A, Domart F, Hahn F, Zeising C, Muth SM, Pape C, Kusch K, Dresbach T, Rizzoli S, Petrovic A, Fernandez-Busnadiego R, A correlative workflow streamlines synaptic imaging by cryo-electron tomography, bioRxiv, 2025, DOI: 10.1101/2025.03.01.640558.
Wittenmayer N, Petkova-Tuffy A, Borgmeyer M, Lee C, Becker J, Böning A, Kügler S, Rhee JS, Viotti JS, Dresbach T, S-SCAM is essential for synapse formation, Front Cell Neurosci, 2023, DOI: 10.3389/fncel.2023.1182493.
Krohn J, Domart F, Do TT, Dresbach T, The synaptic vesicle protein Mover/TPRG1L is associated with lipid droplets in astrocytes, Glia, 2023, DOI: 10.1002/glia.24452.
Ghelani T, Montenegro-Venegas C, Fejtova A, Dresbach T, Nanoscopical analysis reveals an orderly arrangement of the presynaptic scaffold protein Bassoon at the Golgi apparatus, Front Mol Neurosci, 2021, DOI: 10.3389/fnmol.2021.744034.
Petkova-Tuffy A, Gödecke N, Viotti JS, Korte M, Dresbach T, Neuroligin-1 mediates presynaptic maturation through brain-derived neurotrophic factor signaling, BMC Biol, 2021, DOI: 10.1186/s12915-021-01145-7.
Pofantis E, Neher E, Dresbach T, Regulation of a subset of release-ready vesicles by the presynaptic protein Mover, Proc Natl Acad Sci U S A, 2021, DOI: 10.1073/pnas.2022551118.
Viotti JS, Dresbach T, Differential effect on hippocampal synaptic facilitation by the presynaptic protein Mover, Front Synaptic Neurosci, 2019, PMID: 31803042.
Akula AK, Zhang X, Viotti JS, Nestvogel D, Rhee JS, Ebrecht R, Reim K, Wouters F, Liepold T, Jahn O, Bogeski I, Dresbach T, The calmodulin binding region of the synaptic vesicle protein Mover is required for homomeric interaction and presynaptic targeting, Front Mol Neurosci, 2019, PMID: 31787876.
Wallrafen R, Dresbach T, Viotti JS, Quantifying the heterogeneous distribution of a synaptic protein in the mouse brain using immunofluorescence, J Vis Exp, 2019, PMID: 30774137.
Wallrafen R, Dresbach T, The presynaptic protein Mover is differentially expressed across brain areas and synapse types, Front Neuroanat, 2018, DOI: 10.3389/fnana.2018.00058.
Riemann D, Petkova A, Dresbach T, Wallrafen R, An optical assay for synaptic vesicle recycling in cultured neurons overexpressing presynaptic proteins, J Vis Exp, 2018, DOI: 10.3791/58043.
Riemann D, Wallrafen R, Dresbach T, The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein, Sci Rep, 2017, DOI: 10.1038/s41598-017-16004-1.
Körber C, Horstmann H, Venkataramani V, Herrmannsdörfer F, Kremer T, Kaiser M, Schwenger DB, Ahmed S, Dean C, Dresbach T, Kuner T, Modulation of presynaptic release probability by the vertebrate-specific protein Mover, Neuron, 2015, DOI: 10.1016/j.neuron.2015.07.001.
Mendoza Schulz A, Jing Z, Sánchez Caro JM, Wetzel F, Dresbach T, Strenzke N, Wichmann C, Moser T, Bassoon disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse, EMBO J, 2014, DOI: 10.1002/embj.201385887.
Ahmed S, Wittenmayer N, Kremer T, Hoeber J, Akula AK, Urlaub H, Islinger M, Kirsch J, Dean C, Dresbach T, Mover is a homomeric phospho-protein present on synaptic vesicles, PLoS One, 2013, DOI: 10.1371/journal.pone.0063474.
Murk K, Wittenmayer N, Michaelsen-Preusse K, Dresbach T, Schoenenberger CA, Korte M, Jockusch BM, Rothkegel M, Neuronal profilin isoforms are addressed by different signalling pathways, PLoS One, 2012, DOI: 10.1371/journal.pone.0034167.
Schrof S, Staudt T, Rittweger E, Wittenmayer N, Dresbach T, Engelhardt J, Hell SW, STED nanoscopy with mass-produced laser diodes, Opt Express, 2011, DOI: 10.1364/OE.19.008066.
Stan A, Pielarski KN, Brigadski T, Wittenmayer N, Fedorchenko O, Gohla A, Lessmann V, Dresbach T, Gottmann K, Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation, Proc Natl Acad Sci U S A, 2010, DOI: 10.1073/pnas.0914233107.
Wittenmayer N, Körber C, Liu H, Kremer T, Varoqueaux F, Chapman ER, Brose N, Kuner T, Dresbach T, Postsynaptic Neuroligin1 regulates presynaptic maturation, Proc Natl Acad Sci U S A, 2009, DOI: 10.1073/pnas.0905819106.
Tsuriel S, Fisher A, Wittenmayer N, Dresbach T, Garner CC, Ziv NE, Exchange and redistribution dynamics of the cytoskeleton of the active zone molecule Bassoon, J Neurosci, 2009, DOI: 10.1523/JNEUROSCI.4777-08.2009.
Fairless R, Masius H, Rohlmann A, Heupel K, Ahmad M, Reissner C, Dresbach T, Missler M, Polarized targeting of neurexins to synapses is regulated by their C-terminal sequences, J Neurosci, 2008, DOI: 10.1523/JNEUROSCI.5294-07.2008.
Dresbach T, Nawrotzki R, Kremer T, Schumacher S, Quinones D, Kluska M, Kuhse J, Kirsch J, Molecular architecture of glycinergic synapses, Histochem Cell Biol, 2008.
Jose M, Nair DK, Altrock WD, Dresbach T, Gundelfinger ED, Zuschratter W, Investigating interactions mediated by the presynaptic protein Bassoon in living cells by FRET and FLIM, Biophys J, 2008.
Kremer T, Kempf C, Wittenmayer N, Nawrotzki R, Kuner T, Kirsch J, Dresbach T, Mover is a novel vertebrate-specific presynaptic protein with differential distribution at subsets of CNS synapses, FEBS Lett, 2007.
Tsuriel S, Geva R, Zamorano P, Dresbach T, Boeckers T, Gundelfinger ED, Garner CC, Ziv NE, Local sharing as a predominant determinant of synaptic matrix molecular dynamics, PLoS Biol, 2006.
Dresbach T, Torres V, Wittenmayer N, Altrock WD, Zamorano P, Zuschratter W, Nawrotzki R, Ziv NE, Garner CC, Gundelfinger ED, Assembly of active zone precursor vesicles via a trans-Golgi compartment, J Biol Chem, 2006.
Dean C, Dresbach T, Neuroligins and neurexins: linking cell adhesion, synapse formation and cognitive function, Trends Neurosci, 2006.
Reim K, Wegmeyer H, Brandstätter JH, Xue M, Rosenmund C, Dresbach T, Hofmann K, Brose N, Structurally and functionally unique complexins at retinal ribbon synapses, J Cell Biol, 2005.
Boeckers TM, Liedtke T, Spilker C, Dresbach T, Bockmann J, Kreutz MR, Gundelfinger ED, C-terminal synaptic targeting elements for ProSAP/Shank proteins, J Neurochem, 2005.
Dresbach T, Neeb A, Meyer G, Gundelfinger ED, Brose N, Synaptic targeting of neuroligin is independent of neurexin and PSD95 binding, Mol Cell Neurosci, 2004.
Bresler T, Shapira M, Boeckers T, Dresbach T, Futter M, Garner CC, Rosenblum K, Gundelfinger ED, Ziv NE, Postsynaptic density assembly differs from presynaptic active zone assembly, J Neurosci, 2004.
Dresbach T, Hempelmann A, Spilker C, tom Dieck S, Altrock WD, Zuschratter W, Garner CC, Gundelfinger ED, Functional regions of Bassoon, Mol Cell Neurosci, 2003.
Shapira M, Zhai RG, Dresbach T, Bresler T, Torres VI, Gundelfinger ED, Ziv NE, Garner CC, Unitary assembly of presynaptic active zones from Piccolo-Bassoon vesicles, Neuron, 2003.
Altrock WD, tom Dieck S, Sokolov M, Meyer AC, Sigler A, Brakebusch C, Fässler R, Richter K, Boeckers TM, Potschka H, Brandt C, Löscher W, Grimberg D, Dresbach T, Hempelmann A, Hassan H, Balschun D, Frey JU, Brandstätter JH, Garner CC, Rosenmund C, Gundelfinger ED, Functional inactivation of excitatory synapses in bassoon-deficient mice, Neuron, 2003.
Spilker C, Dresbach T, Braunewell KH, Activity-dependent localization of VILIP-1 in neurons, J Neurosci, 2002.
Kraemer D, Dresbach T, Drenckhahn D, Mrnp41 associates with microtubules, Eur J Cell Biol, 2001.
Dresbach T, Qualmann B, Kessels MM, Garner CC, Gundelfinger ED, The presynaptic cytomatrix of brain synapses, Cell Mol Life Sci, 2001.
Sanmartí-Vila L, tom Dieck S, Richter K, Altrock W, Zhang L, Volknandt W, Zimmermann H, Garner CC, Gundelfinger ED, Dresbach T, Membrane association of Bassoon, Biochem Biophys Res Commun, 2000.
Bracher A, Perrakis A, Dresbach T, Betz H, Weissenhorn W, X-ray structure of neuronal Sec1, Structure, 2000.
Bracher A, Dresbach T, Betz H, Weissenhorn W, Crystallization of squid neuronal Sec1, Acta Crystallogr D, 2000.
el Far O, O’Connor V, Dresbach T, Pellegrini L, DeBello W, Schweizer F, Augustine G, Heuss C, Schäfer T, Charlton MP, Betz H, Protein interactions in neurotransmitter release, J Physiol Paris, 1998.
Dresbach T, Burns ME, O’Connor V, DeBello WM, Betz H, Augustine GJ, A neuronal Sec1 homolog regulates neurotransmitter release, J Neurosci, 1998.
Schweizer FE, Dresbach T, DeBello WM, O’Connor V, Augustine GJ, Betz H, Regulation of neurotransmitter release kinetics by NSF, Science, 1998.
O’Connor V, Heuss C, DeBello WM, Dresbach T, Charlton MP, Hunt JH, Pellegrini LL, Hodel A, Burger MM, Betz H, Augustine GJ, Schäfer T, Disruption of syntaxin-mediated interactions blocks secretion, Proc Natl Acad Sci U S A, 1997.
O’Connor V, Pellegrini L, Dresbach T, Bommert K, el Far O, Betz H, DeBello W, Hunt JM, Schweizer F, Augustine G, Charlton MP, Protein-protein interactions in synaptic vesicle exocytosis, Biochem Soc Trans, 1996.
DeBello WM, O’Connor V, Dresbach T, Whiteheart SW, Wang SS, Schweizer FE, Betz H, Rothman JE, Augustine GJ, SNAP-mediated interactions essential for neurotransmitter release, Nature, 1995.
Burns ME, Beushausen SA, Chin GJ, Tang D, DeBello WM, Dresbach T, O’Connor V, Schweizer FE, Wang SS, Whiteheart SW, Proteins involved in synaptic vesicle docking and fusion, Cold Spring Harb Symp Quant Biol, 1995.

Original Research Works (AGs ehemaliger Professoren am Institut) 2020 - 2025